ROSE GERANIUM ESSENTIAL OIL RESTORATIVE POTENTIAL ON LEAD ACETATE INDUCED OVARY TOXICITY USING A MOUSE MODEL
Massinissa Madouche
a:1:{s:5:"en_US";s:37:"Mouloud Mammeri University Tizi Ouzou";}https://orcid.org/0009-0005-6187-4806
Nacera Boulila
Mouloud Mammeri University Tizi Ouzouhttps://orcid.org/0000-0001-7091-6581
Lynda Lakabi
Mouloud Mammeri University Tizi Ouzouhttps://orcid.org/0000-0002-9747-4223
Samira Akdader
Mouloud Mammeri University Tizi OuzouFerroudja Medjdoub-Bensaad
Mouloud Mammeri University Tizi OuzouAbstract
It is well known that lead cause tissue damage, dysfunction of folliculogenesis and elevated follicular. Rose geranium essential oil has anti-inflammatory and antioxidant properties and could have therapeutic potential. 18 adult BALB/c mice were used in this study and divided into 3 groups. Group I received physiological water, groups II and III received a single low dose of lead acetate and after 7 days, group III received daily dose of 300µl/Kg of essential oil. Histological samples from group (II) treated with 8mg/Kg of lead acetate reveals altered ovarian structure and those of group (III) treated with 300µl/Kg of geranium essential oil showed an improved ovarian structure. Antral follicles atresia is higher in group (II) than in the other two groups. Our results indicate that a treatment with daily doses of rose geranium essential oil improved the lead-altered ovarian structure and reduced the degeneration of antral follicles.
Keywords:
ovary, geranium, essential oil, lead acetate, reproductionReferences
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a:1:{s:5:"en_US";s:37:"Mouloud Mammeri University Tizi Ouzou";}
https://orcid.org/0009-0005-6187-4806
Mouloud Mammeri University Tizi Ouzou
Mouloud Mammeri University Tizi Ouzou