Apathy Syndrome in Neurological Diseases – State of the Art and Current Research Directions

Abramzon, Y. A., Fratta, P., Traynor, B. J., & Chia, R. (2020). The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Frontiers in Neuroscience, 14, article 42. https://doi.org/10.3389/fnins.2020.00042
Crossref   Google Scholar

Andersson, S., & Bergedalen, A. M. (2002). Cognitive correlates of apathy in traumatic brain injury. Neuropsychiatry, Neuropsychology, & Behavioral Neurology, 15, 184–191.   Google Scholar

Andersson, S., Krogstad, J. M., & Finset, A. (1999). Apathy and depressed mood in acquired brain damage: relationship to lesion localization and psychophysiological reactivity. Psychological Medicine, 29, 447–456. https://doi.org/10.1017/s0033291798008046
Crossref   Google Scholar

Ang, Y. S., Lockwood, P., Apps, M. A., Muhammed, K., & Husain, M. (2017). Distinct Subtypes of Apathy Revealed by the Apathy Motivation Index. Plos One, 12(1), https://doi.org/10.1037/t77043-000
Crossref   Google Scholar

Angelelli, P., Paolucci, S., Bivona, U., Piccardi, L., Ciurli, P., Cantagallo, A., Antonucci, G., Fasotti, L., Di Santantonio, A., Grasso, M. G., & Pizzamiglio, L. (2004). Development of neuropsychiatric symptoms in poststroke patients: a cross-sectional study. Acta Psychiatrica Scandinavica, 110(1), 55–63. https://doi.org/10.1111/j.1600-0447.2004.00297.x
Crossref   Google Scholar

Arnould, A., Rochat, L., Azouvi, P., & Van der Linden, M. (2015). Apathetic symptom presentations in patients with severe traumatic brain injury: Assessment, heterogeneity and relationships with psychosocial functioning and caregivers’ burden. Brain Injury, 29(13–14), 1597–1603. https://doi.org/10.3109/02699052.2015.1075156
Crossref   Google Scholar

Baake, V., Coppen, E. M., van Duijn, E., Dumas, E. M., van den Bogaard, S., Scahill, R. I, Johnson, H., Leavitt, B., Durr, A., Tabrizi, S. J., Craufurd, D., & Roos, R. (2018). Apathy and atrophy of subcortical brain structures in Huntington's disease: A two-year follow-up study. NeuroImage: Clinical, 19, 66–70. https://doi.org/doi:10.1016/j.nicl.2018.03.033
Crossref   Google Scholar

Bathgate, D., Snowden, J. S., Varma, A., Blackshaw, A., & Neary, D. (2001). Behaviour in frontotemporal dementia, Alzheimer’s disease and vascular dementia. Acta Neurologica Scandinavica, 103, 367–378. https://doi.org/10.1034/j.1600-0404.2001.2000236.x
Crossref   Google Scholar

Bayen, E., Pradat-Diehl, P., Jourdan, C., Ghout, I., Bosserelle, V., Azerad, S., Weiss, J., Joël, M., Aegerter, P., & Azouvi, P. (2013). Predictors of informal care burden 1 year after a severe traumatic brain injury: results from the PariS-TBI study. Journal of Head Trauma Rehabilitation, 28(6), 408–418. https://doi.org/10.1097/htr.0b013e31825413cf
Crossref   Google Scholar

Benoit, M., Clairet, S., Koulibaly, P. M., Darcourt, J., & Robert, P. H. (2004). Brain perfusion correlates of the apathy inventory dimensions of Alzheimer's disease. International Journal of Geriatric Psychiatry, 19(9), 864–869. https://doi.org/10.1002/gps.1163
Crossref   Google Scholar

Bhatia, K. P., & Marsden, C. D. (1994). The behavioural and motor consequences of focal lesions of the basal ganglia in man. Brain: A Journal of Neurology, 117(4), 859–876. https://doi.org/10.1093/brain/117.4.859
Crossref   Google Scholar

Bjoerke-Bertheussen, J., Ehrt, U., Rongve, A., Ballard, C., & Aarsland, D. (2012). Neuropsychiatric symptoms in mild dementia with Lewy bodies and Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 34(1), 1–6. https://doi.org/10.1159/000339590
Crossref   Google Scholar

Bonnelle, V., Manohar, S., Behrens, T., & Husain, M. (2016). Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy. Cerebral Cortex, 26(2), 807–819. https://doi.org/10.1093/cercor/bhv247
Crossref   Google Scholar

Breitve, M. H., Brønnick, K., Chwiszczuk, L. J., Hynninen, M. J., Aarsland, D., & Rongve, A. (2018). Apathy is associated with faster global cognitive decline and early nursing home admission in dementia with Lewy bodies. Alzheimer's Research & Therapy, 10(1), article 83. https://doi.org/10.1186/s13195-018-0416-5
Crossref   Google Scholar

Brett, C., Sykes, C., & Pires-Yfantouda, R. (2017). Interventions to increase engagement with rehabilitation in adults with acquired brain injury: A systematic review. Neuropsychological Rehabilitation, 27(6), 959–982. https://doi.org/10.1080/09602011.2015.1090459
Crossref   Google Scholar

Brodaty, H., Sachdev, P., Withall, A., Altendorf, A., Valenzuela, M., & Lorentz, L. (2005). Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke – the Sydney Stroke Study. Psychological Medicine, 35(12), 1707–1716. https://doi.org/10.1017/S0033291705006173
Crossref   Google Scholar

Carnes-Vendrell, A., Deus, J., Molina-Seguin, J., Pifarré, J., & Purroy, F. (2019). Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution, and Predictors. Scientific Reports, 9(1), article 16248. https://doi.org/10.1038/s41598-019-52721-5
Crossref   Google Scholar

Carrera, E., & Bogousslavsky, J. (2006). The thalamus and behavior: effects of anatomically distinct strokes. Neurology, 66(12), 1817–1823. https://doi.org/10.1212/01.wnl.0000219679.95223.4c
Crossref   Google Scholar

Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994). The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology, 44(12), 2308–2314. https://doi.org/10.1212/WNL.44.12.2308
Crossref   Google Scholar

Da Costa, R., Porto, F., & Marrocos, R. (2013). Dissociation of depression from apathy in traumatic brain injury: a case report. Dementia & Neuropsychologia, 7(3), 312–315. https://doi.org/10.1590/s1980-57642013dn70300014
Crossref   Google Scholar

De Paepe, A., Sierpowska, J., Garcia-Gorro, C., Martinez-Horta, S., Perez-Perez, J., Kulisevsky, J., Rodriguez-Dechicha, N., Vaquer, I., Subira, S., Calopa, M., Muñoz, E., Santacruz, P., Ruiz-Idiago, J., Mareca, C., de Diego-Balaguer, R., & Camara, E. (2019). White matter cortico-striatal tracts predict apathy subtypes in Huntington's disease. Neuroimage: Clinical, 24, article 101965. https://doi.org/10.1016/j.nicl.2019.101965
Crossref   Google Scholar

Derouesné, C., Lacomblez, L., Fiori, N., Gély-Nargeot, M., & Bungener, C. (2012). L'apathie dans la démence frontemporale et la maladie d'Alzheimer: existe-t-il des profils distincts? [Apathy in frontotemporal dementia and Alzheimer's disease: are there distinct profiles?]. Geriatrie et Psychologie Neuropsychiatrie du Vieillissement, 10(1), 107–115. https://doi.org/10.1684/pnv.2012.0315
Crossref   Google Scholar

De Witte, L., Engelborghs, S., Verhoeven, J., De Deyn, P., & Mariën, P. (2008). Disrupted auto-activation, dysexecutive and confabulating syndrome following bilateral thalamic and right putaminal stroke. Behavioural Neurology, 19(3), 145–151. https://dx.doi.org/10.1155/2008/693671
Crossref   Google Scholar

Diehl-Schmid, J., Schmidt, E-M., & Nunnemann, S. (2013). Caregiver burden and needs in frontotemporal dementia. Journal of Geriatric Psychiatry and Neurology, 26(4), 221–229. https://doi.org/10.1177/0891988713498467
Crossref   Google Scholar

D’Iorio, A., Vitale, C., Piscopo, F., Baiano, C., Falanga, A. P., Longo, K., & Santangelo, G. (2017). Impact of anxiety, apathy and reduced functional autonomy on perceived quality of life in Parkinson's disease. Parkinsonism & Related Disorders, 43, 114–117. https://doi.org/10.1016/j.parkreldis.2017.08.003
Crossref   Google Scholar

Douven, E., Kohler, S., & Schievink, S. (2017). Temporal associations between fatigue, depression, and apathy after stroke: results of the cognition and affect after stroke, a prospective evaluation of risks study. Cerebrovascular Diseases, 44, 330–337. https://doi.org/10.1159/000481577
Crossref   Google Scholar

Drevets, W. (1999). Prefrontal cortical-amygdalar metabolism in major depression. Annals of the New York Academy of Sciences, 877, 614–637. https://doi.org/10.1111/j.1749-6632.1999.tb09292.x
Crossref   Google Scholar

Drevets, W., Price, J., Bardgett, M., Reich, T., Todd, R., & Raichle, M. (2002). Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levels. Pharmacology Biochemistry and Behaviour, 71(3), 431–447. https://doi.org/10.1016/S0091-3057(01)00687-6.
Crossref   Google Scholar

Drevets, W., Videen, T., Price, J., Preskorn, S., Carmichael, S., & Raichle, M. (1992). A functional anatomical study of unipolar depression. The Journal of Neuroscience, 12, 3628–3641. https://doi.org/10.1523/JNEUROSCI.12-09-03628.1992
Crossref   Google Scholar

Fernández-Matarrubia, M., Matías-Guiu, J., Cabrera-Martín, M., Moreno-Ramos, T., Valles-Salgado, M., Carreras, J., & Matías-Guiu, J. (2017). Different apathy clinical profile and neural correlates in behavioral variant frontotemporal dementia and Alzheimer's disease. International Journal of Geriatric Psychiatry, 33(1), 141–150. https://doi.org/10.1002/gps.4695
Crossref   Google Scholar

Fisher, C. (1983). Honored guest presentation: abulia minor vs agitated behavior. Clinical Neurosurgery, 31, 9–31. https://doi.org/10.1093/neurosurgery/31.cn_suppl_1.9
Crossref   Google Scholar

Flavell, J., & Nestor, P. (2022). A Systematic Review of Apathy and Depression in Progressive Supranuclear Palsy. Journal of Geriatric Psychiatry and Neurology, 35(3), 280–292. https://doi.org/10.1177/0891988721993545
Crossref   Google Scholar

Giordana, M. T., Ferrero, P., Grifoni, S., Pellerino, A., Naldi, A., & Montuschi, A. (2011). Dementia and cognitive impairment in amyotrophic lateral sclerosis: a review. Neurological Sciences, 32(1), 9–16. https://doi.org/10.1007/s10072-010-0439-6
Crossref   Google Scholar

Guild, E., & Levine, B. (2015). Functional Correlates of Midline Brain Volume Loss in Chronic Traumatic Brain Injury. Journal of the International Neuropsychological Society, 21(8), 650–655. https://doi.org/10.1017/s1355617715000600
Crossref   Google Scholar

Habib, M. (2004). Athymhormia and Disorders of Motivation in Basal Ganglia Disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 16(4), 509–524. https://doi.org/10.1176/JNP.16.4.509
Crossref   Google Scholar

Hama, S., Yamashita, H., Shigenobu, M., Watanabe, A., Hiramoto, K., Kurisu, K., Yamawaki, S., & Kitaoka, T. (2007). Depression or apathy and functional recovery after stroke. International Journal of Geriatric Psychiatry, 22(10), 1046–1051. https://doi.org/10.1002/gps.1866
Crossref   Google Scholar

Ishizaki, J., & Mimura, M. (2011). Dysthymia and apathy: diagnosis and treatment. Depression Research and Treatment, article ID 893905, 1–7. https://doi.org/10.1155/2011/893905
Crossref   Google Scholar

Jaracz, J. (2008). Anatomia depresji w świetle wyników badań neuroobrazowych [The anatomy of depression in light of evidence from neuroimaging studies]. Psychiatria Polska [Polish Psychiatry], 42(6), 875–888.   Google Scholar

Jeong, H., Kang, I., Im, J. J., Park, J. S., Na, S. H., Heo, Y., Yang, Y., Chung, Y. A., & Song, I. U. (2018). Brain Perfusion Correlates of Apathy in Alzheimer's Disease. Dementia and Neurocognitive Disorders, 17(2), 50–56. https://doi.org/10.12779/dnd.2018.17.2.50
Crossref   Google Scholar

Jorge, R., Starkstein, S., & Robinson, R. (2010). Apathy following Stroke. The Canadian Journal of Psychiatry, 55(6), 350–354. https://doi.org/10.1177/070674371005500603
Crossref   Google Scholar

Krishnamoorthy, A., & Craufurd, D. (2011). Treatment of Apathy in Huntington’s Disease and Other Movement Disorders. Current Treatment Options in Neurology, 13, 508–519. https://doi.org/10.1007/s11940-011-0140-y
Crossref   Google Scholar

Lanctôt, K. L., Agüera-Ortiz, L., Brodaty, H., Francis, P. T., Geda, Y. E., Ismail, Z., Marshall, G. A., Mortby, M. E., Onyike, C. U., Padala, P. R., Politis, A. M., Rosenberg, P. B., Siegel, E., Sultzer, D. L., & Abraham, E. H. (2017). Apathy associated with neurocognitive disorders: Recent progress and future directions. Alzheimer's & Dementia, 13, 84–100. https://doi.org/10.1016/j.jalz.2016.05.008
Crossref   Google Scholar

Laplane, D., Baulac, M., Widlöcher, D., & Dubois, B. (1984). Pure psychic akinesia with bilateral lesions of basal ganglia. Journal of Neurology, Neurosurgery, and Psychiatry, 47(4), 377–385. https://doi.org/10.1136%2Fjnnp.47.4.377
Crossref   Google Scholar

Lázaro-Perlado, F. (2019). Apathy: A Conceptual Review. Current Psychiatry Research and Reviews, 15, 88–104. http://dx.doi.org/10.2174/1573400515666190306150306
Crossref   Google Scholar

Le Heron, C., Apps, M., & Husain, M. (2018). The anatomy of apathy: A neurocognitive framework for amotivated behaviour. Neuropsychologia, 118(Pt B), 54–67. https://doi.org/10.1016/j.neuropsychologia.2017.07.003
Crossref   Google Scholar

Leśniak, M., Roessler-Górecka, M., Członkowska, A., & Seniów, J. (2022). Clinical significance of self-descriptive apathy assessment in patients with neurological form of Wilson's disease. Neurological Sciences, 43(2), 1385–1394. https://doi.org/10.1007/s10072-021-05366-0
Crossref   Google Scholar

Levy, M. L., Cummings, J. L., Fairbanks, L. A., Masterman, D., Miller, B. L., Craig, A. H., Paulsen, J. S., & Litvan, I. (1998). Apathy is not depression. The Journal of Neuropsychiatry and Clinical Neurosciences, 10(3), 314–319. https://doi.org/10.1176/jnp.10.3.314
Crossref   Google Scholar

Levy, R. (2012). Apathy: a pathology of goal-directed behaviour. A new concept of the clinic and pathophysiology of apathy. Revue Neurologique, 168(8), 585–597. https://doi.org/10.1016/j.neurol.2012.05.003
Crossref   Google Scholar

Levy, R., & Dubois, B. (2006). Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cerebral Cortex, 16(7), 916–928. https://doi.org/10.1093/cercor/bhj043
Crossref   Google Scholar

Lillo, P., Mioshi, E., Zoing, M., Kiernan, M., & Hodges, J. (2011). How common are behavioural changes in amyotrophic lateral sclerosis? Amyotrophic Lateral Sclerosis, 12(1), 45–51. https://doi.org/10.3109/17482968.2011.639376
Crossref   Google Scholar

Litvan, I., Mega, M., Cummings, J., & Fairbanks, L. (1996). Neuropsychiatric aspects of progressive supranuclear palsy. Neurology, 47, 1184–1189. https://doi.org/10.1212/WNL.47.5.1184
Crossref   Google Scholar

Ma, L. (2020). Depression, anxiety, and apathy in mild cognitive impairment: Current perspectives. Frontiers in Aging Neuroscience, 12, article 9. https://doi.org/10.3389/fnagi.2020.00009
Crossref   Google Scholar

Madhusoodanan, S., Ting, M., Farah, T., & Ugur, U. (2015). Psychiatric aspects of brain tumors: A review. World Journal of Psychiatry, 5(3), 273–285. https://doi.org/10.5498/wjp.v5.i3.273
Crossref   Google Scholar

Marin, R. (1990). Differential diagnosis and classification of apathy. American Journal of Psychiatry, 147(1), 22–30. https://doi.org/10.1176/ajp.147.1.22
Crossref   Google Scholar

Marin, R. (1991). Apathy: a neuropsychiatric syndrome. The Journal of Neuropsychiatry and Clinical Neurosciences, 3(3), 243–254. https://doi.org/10.1176/jnp.3.3.243
Crossref   Google Scholar

Marin, R., & Wilkosz, P. (2005). Disorders of diminished motivation. The Journal of Head Trauma Rehabilitation, 20(4), 377–388. https://doi.org/10.1097/00001199-200507000-00009
Crossref   Google Scholar

Marin, R. S., Biedrzycki, R. C., & Firinciogullari, S. (1991). Reliability and validity of the Apathy Evaluation Scale. Psychiatry Research, 38(2), 143–162. https://doi.org/10.1016/0165-1781(91)90040-v
Crossref   Google Scholar

McFarland, B., & Klein, D. (2009). Emotional reactivity in depression: diminished responsiveness to anticipated reward but not to anticipated punishment or to nonreward or avoidance. Depression and Anxiety, 26(2), 117–122. https://doi.org/10.1002/da.20513
Crossref   Google Scholar

Mele, B., Van, S., Holroyd-Leduc, J., Ismail, Z., Pringsheim, T., & Goodarzi, Z. (2020). Diagnosis, treatment and management of apathy in Parkinson's disease: a scoping review. BMJ Open, 10(9), https://doi.org/10.1136/bmjopen-2020-037632
Crossref   Google Scholar

Merrilees, J., Dowling, G., Hubbard, E., Mastick, J., Ketelle, R., & Miller, B. (2013). Characterization of apathy in persons with frontotemporal dementia and the impact on family caregivers. Alzheimer Disease and Associated Disorders, 27(1), 62–67. https://doi.org/10.1097/wad.0b013e3182471c54
Crossref   Google Scholar

Millar, D., Griffiths, P., Zermansky, A., & Burn, D. (2006). Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy. Movement Disorders, 21(2), 199–207. https://doi.org/10.1002/mds.20707
Crossref   Google Scholar

Miller, D. S., Robert, P., Ereshefsky, L., Adler, L., Bateman, D., Cummings, J., DeKosky, S. T., Fischer, C. E., Husain, M., Ismail, Z., Jaeger, J., Lerner, A. J., Li, A., Lyketsos, C. G., Manera, V., Mintzer, J., Moebius, H. J., Mortby, M., Meulien, D., … Lanctôt, K. L. (2021). Diagnostic criteria for apathy in neurocognitive disorders. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 17(12), 1892–1904. https://doi.org/10.1002/alz.12358
Crossref   Google Scholar

Monsalve, C., B., Guitart, B. M., López, R., Vilasar, B. A., & Quemada, J. (2012). Perfil psicopatológico de pacientes con traumatismo craneoencefálico evaluados mediante el Inventario Neuropsiquiátrico [Psychopatological evaluation of traumatic brain injury patients with the Neuropsychiatric Inventory]. Revista de Psiquiatria y Salud Mental, 5(3), 160–166.
Crossref   Google Scholar

Motomura, K., Kawamura, A., Ohka, F., Aoki, K., Nishikawa, T., Yamaguchi, J., Kibe, Y., Shimizu, H., Maeda, S., & Saito, R. (2023). Predictive factors of post-operative apathy in patients with diffuse frontal gliomas undergoing awake brain mapping. Journal of Neuropsychology, 18(S1), 73–84. https://doi.org/10.1111/jnp.12345
Crossref   Google Scholar

Naarding, P., Janzing, J., Eling, P., van der Werf, S., & Kremer, B. (2009). Apathy is not depression in Huntington’s disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 21, 266–270. https://doi.org/10.1176/jnp.2009.21.3.266
Crossref   Google Scholar

Nobis, L., & Husain, M. (2018). Apathy in Alzheimer's disease. Current Opinion in Behavioral Sciences, 22, 7–13. https://doi.org/10.1016/j.cobeha.2017.12.007
Crossref   Google Scholar

Pachi, I., Koros, C., Simitsi, A., Papadimitriou, D., Bougea, A., Prentakis, A., Papagiannakis, N., Bozi, M., Antonelou, R., Angelopoulou, E., Beratis, I., Stamelou, M., Trapali, X., Papageorgiou, S., & Stefanis, L. (2021). Apathy: An underestimated feature in GBA and LRRK2 non-manifesting mutation carriers. Parkinsonism and Related Disorders, 91, 1–8. https://doi.org/10.1016/j.parkreldis.2021.08.008
Crossref   Google Scholar

Pagonabarraga, J., Kulisevsky, J., Strafella, A., & Krack, P. (2015). Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment. The Lancet Neurology, 14(5), 518–531. https://doi.org/10.1016/s1474-4422(15)00019-8
Crossref   Google Scholar

Peng, Y., Shao, Ch., Gong, Y., Wu, X., Tang, W., & Shi, S. (2015). Relationship between apathy and tumor location, size, and brain edema in patients with intracranial meningioma, Neuropsychiatric Disease and Treatment, 11, 1685–1693. https://doi.org/10.2147/ndt.s85288
Crossref   Google Scholar

Pluck, G., & Brown, R. (2002). Apathy in Parkinson’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 73, 636–642. https://doi.org/10.1136/jnnp.73.6.636
Crossref   Google Scholar

Pont-Sunyer, C., Hotter, A., Gaig, C., Seppi, K., Compta, Y., Katzenschlager, R., Mas, N., Hofeneder, D., Brücke, T., Bayés, A., Wenzel, K., Infante, J., Zach, H., Pirker, W., Posada, I. J., Álvarez, R., Ispierto, L., De Fàbregues, O., Callén, A., … Tolosa, E. (2015). The Onset of Nonmotor Symptoms in Parkinson's disease (The ONSET PD Study). Movement Disorders, 30, 229–237. https://doi.org/10.1002/mds.26077
Crossref   Google Scholar

Radakovic, R., & Abrahams, S. (2014). Developing a new apathy measurement scale: Dimensional Apathy Scale. Psychiatry Research, 219(3), 658–663. https://doi.org/10.1016/j.psychres.2014.06.010
Crossref   Google Scholar

Radakovic, R., Davenport, R., Starr, J., & Abrahams, S. (2018). Apathy dimensions in Parkinson's disease. International Journal of Geriatric Psychiatry, 33(1), 151–158. https://doi.org/10.1002/gps.4697
Crossref   Google Scholar

Radakovic, R., Stephenson, L., Colville, S., Swingler, R., Chandran, S., & Abrahams, S. (2016). Multidimensional apathy in ALS: validation of the Dimensional Apathy Scale. Journal of Neurology, Neurosurgery & Psychiatry, 87(6), 663–669.
Crossref   Google Scholar

Radakovic, R., Stephenson, L., Newton, J., Crockford, C., Swingler, R., Chandran, S., & Abrahams, S. (2017). Multidimensional Apathy and Executive Dysfunction in Amyotrophic Lateral Sclerosis. Cortex, 94, 142–151. https://doi.org/10.1016/j.cortex.2017.06.023
Crossref   Google Scholar

Ready, R., Mathews, M., Leserman, A., & Paulsen, J. (2008). Patient and caregiver quality of life in Huntington's disease. Movement Disorders, 23(5), 721–726. https://doi.org/10.1002/mds.21920
Crossref   Google Scholar

Robert, P., Lanctôt, K., Agüera-Ortiz, L., Aalten, P., Bremond, F., Defrancesco, M., Hanon, C., David, R., Dubois, B., Dujardin, K., Husain, M., König, A., Levy, R., Mantua, V., Meulien, D., Miller, D., Moebius, H., Rasmussen, J., Robert, G., … Manera, V. (2018). Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group. European Psychiatry, 54, 71–76. https://doi.org/10.1016/j.eurpsy.2018.07.008
Crossref   Google Scholar

Robert, P., Onyike, C. U., Leentjens, A. F., Dujardin, K., Aalten, P., Starkstein, S., Verhey, F. R., Yessavage, J., Clement, J. P., Drapier, D., Bayle, F., Benoit, M., Boyer, P., Lorca, P. M., Thibaut, F., Gauthier, S., Grossberg, G., Vellas, B., & Byrne, J. (2009). Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders. European Psychiatry, 24(2), 98–104. https://doi.org/10.1016/j.eurpsy.2008.09.001
Crossref   Google Scholar

Santa, N., Sugimori, H., Kusuda, K., Yamashita, Y., Ibayashi, S., & Iida, M. (2008). Apathy and functional recovery following first-ever stroke. International Journal of Rehabilitation Research, 31(4), 321–326. https://doi.org/10.1097/MRR.0b013e3282fc0f0e
Crossref   Google Scholar

Seniów, J., Komajda, R., & Zaborski, J. (2005). Zespół apatii w konsekwencji uszkodzenia mózgu – trudny problem neurorehabilitacji [Apathy syndrome as a consequence of brain injury – a difficult problem in neurorehabilitation]. Rehabilitacja Medyczna [Medical Rehabilitation], 9(2), 15–19.   Google Scholar

Sockeel, P., Dujardin, K., Devos, D., Denève, C., Destée, A., & Defebvre, L. (2006). The Lille apathy rating scale (LARS), a new instrument for detecting and quantifying apathy: validation in Parkinson’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 77(5), 579–584. https://doi.org/10.1136/jnnp.2005.075929
Crossref   Google Scholar

Stanton, B., Leigh, P., Howard, R., Barker, G., & Brown, R. (2013). Behavioural and emotional symptoms of apathy are associated with distinct patterns of brain atrophy in neurodegenerative disorders. Journal of Neurology, 260(10), 2481–2490. https://doi.org/10.1007/s00415-013-6989-9
Crossref   Google Scholar

Starkstein, S., Fedoroff, J., Price, T., Leiguarda, R., & Robinson, R. (1993). Apathy following cerebrovascular lesions. Stroke, 24(11), 1625–1630. https://doi.org/10.1161/01.str.24.11.1625
Crossref   Google Scholar

Starkstein, S., & Manes, F. (2000). Apathy and depression following stroke. CNS Spectrums, 5(3), 43–50. https://doi.org/10.1017/s1092852900012955
Crossref   Google Scholar

Starkstein, S., Mayberg, H., Preziosi, T., Andrezejewski, P., Leiguarda, R., & Robinson, R. (1992). Reliability, validity, and clinical correlates of apathy in Parkinsons disease. Journal of Neuropsychiatry and Clinical Neurosciences, 4(2), 134–139. https://doi.org/10.1176/jnp.4.2.134
Crossref   Google Scholar

Starkstein, S., Merello, M., Jorge, R., Brockman, S., Bruce, D., & Power, B. (2009). The syndromal validity and nosological position of apathy in Parkinson's disease. Movement Disorders, 24(8), 1211–1216. https://doi.org/10.1002/mds.22577
Crossref   Google Scholar

Starkstein, S., & Pahissa, J. (2014). Apathy following traumatic brain injury. The Psychiatric clinics of North America, 37(1), 103–112. https://doi.org/10.1016/j.psc.2013.10.002
Crossref   Google Scholar

Starkstein, S., Petracca, G., Chemerinski, E., & Kremer, J. (2001). Syndromic validity of apathy in Alzheimer’s disease. The American Journal of Psychiatry, 158(6), 872–877. https://doi.org/10.1176/appi.ajp.158.6.872
Crossref   Google Scholar

Steffens, D. C., Fahed, M., Manning, K. J., & Wang, L. (2022). The neurobiology of apathy in depression and neurocognitive impairment in older adults: a review of epidemiological, clinical, neuropsychological and biological research. Translational Psychiatry, 12(1), https://doi.org/10.1038/s41398-022-02292-3
Crossref   Google Scholar

Stuss, D. (2011). Functions of the frontal lobes: relation to executive functions. Journal of the International Neuropsychological Society, 17(5), 759–765. https://psycnet.apa.org/doi/10.1017/S1355617711000695
Crossref   Google Scholar

Stuss, D., & Benson, F. (1986). The Frontal Lobes. Raven Press.   Google Scholar

Stuss, D., van Reekum, R., & Murphy, K. (2000). Differentiaton of states and causes of apathy. In J. Borod (Ed.), The neuropsychology of emotion (pp. 340–352). Oxford University Press.   Google Scholar

Tay, J., Morris, R., & Markus, H. (2021). Apathy after stroke: Diagnosis, mechanisms, consequences, and treatment. International Journal of Stroke, 16(5), 510–518. https://doi.org/10.1177/1747493021990906
Crossref   Google Scholar

Tay, J., Morris, R., Tuladhar, A., Husain, M., de Leeuw, F., & Markus, H. (2020). Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease. Journal of Neurology, Neurosurgery & Psychiatry, 91(9), 953–959. https://doi.org/10.1136/jnnp-2020-323092
Crossref   Google Scholar

Theleritis, C. (2017). Pharmacological and Nonpharmacological Treatment for Apathy in Alzheimer Disease: A systematic review across modalities. The Journal of Geriatric Psychiatry and Neurology, 30(1), 26–49. https://doi.org/10.1177/0891988716678684
Crossref   Google Scholar

Thompson, J., Harris, J., & Sollom, A. (2012). Longitudinal evaluation of neuropsychiatric symptoms in Huntington’s disease. Journal of Neuropsychiatry and Clinical Neurosciences, 24, 53–60. https://doi.org/10.1176/appi.neuropsych.11030057
Crossref   Google Scholar

Zarandy, J., Yoon, S., Saravanan, S., Das, S., & Thomas, S. (2023). Differential Diagnostic Considerations in a Patient With New Onset Apathy: A Case Study on Frontal Lobe Glioblastoma Multiforme. The Journal of Integrated Primary Care, 1(1), article 3. https://digitalcommons.pcom.edu/jipc/vol1/iss1/3   Google Scholar

Zoon, T., van Rooijen, G., Balm, G., Bergfeld, I., Daams, J., Krack, P., Denys, D., & de Bie, R. (2021). Apathy Induced by Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease: A Meta-Analysis. Movement Disorders, 36(2), 317–326. https://doi.org/10.1002/mds.28390
Crossref   Google Scholar