Altrock W.D., Tom Dieck S., Sokolov M., Meyer A.C., Sigler A., Brakebusch C., Fassler R., Richter K., Boeckers T.M., Potschka H., Brandt C., Loscher W., Grimberg D., Dresbach T., Hempelmann A., Hassan H., Balschun D., Frey J.U., Brandstatter J.H., Garner C.C., Rosenmund C., Gundelfinger E.D. (2003) Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. „Neuron” 37:787-800.

Angenstein F., Niessen H.G., Goldschmidt J., Lison H., Altrock W.D., Gundelfinger E.D., Scheich H. (2007) Manganese-enhanced MRI reveals structural and functional changes in the cortex of Bassoon mutant mice. „Cereb. Cortex” 17:28-36.

Augustin I., Rosenmund C., Sudhof T.C., Brose N. (1999) Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles. „Nature” 400:457-461.

Aravamudan B., Fergestad T., Davis W.S., Rodesch C.K., Broadie K. (1999) Drosophila UNC-13 is essential for synaptic transmission. „Nat. Neurosci.” 2:965-971.

Betz A., Ashery U., Rickmann M., Augustin I., Neher E., Sudhof T.C., Rettig J., Brose N. (1998) Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release. „Neuron” 21:123-136.

Betz A., Thakur P., Junge H.J., Ashery U., Rhee J.S., Scheuss V., Rosenmund C., Rettig J.,

Brose N. (2001) Functional interaction o f the active zone proteins Munc13-1 and R1M1 in synaptic vesicle priming. „Neuron” 30:183-196. Brose N., Hofmann K., Hata Y., Sudhof T.C. (1995) Mammalian homologues o f Caenorhabditis elegans unc-13 gene define novel family o f C2-domain proteins. „J. Biol. Chem.” 270:25273¬ -25280.

Cases-Langhoff C., Voss B., Garner A.M., Appeltauer U., Takei K., Kindler S., Veh R.W., De Camilli P., Gundelfinger E.D., Garner C.C. (1996) Piccolo, a novel 420 kDa protein associated with the presynaptic cytomatrix. „Eur. J. Cell. Biol.” 69:214-223.

Couteaux R., Pecot-Dechavassine M. (1970) Vesicules synaptiques etpoches au niveau des „zones actives" de lajonction neuromusculaire. „CR Seances Acad. Sci.” Ser. D 271:2346-2349.

Dick O., Tom Dieck S., Altrock W.D., Ammermuller J., Weiler R., Garner C.C., Gundelfinger E.D., Brandstatter J.H. (2003) The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina. „Neuron” 37:775-786.

Fenster S.D., Chung W.J., Zhai R., Cases-Langhoff C., Voss B., Garner A.M., Kaempf U., Kindler S., Gundelfinger E.D., Garner C.C. (2000) Piccolo, a presynaptic zinc finger protein structurally related to Bassoon. „Neuron” 25:203-214.

Kaufmann N., De Proto J., Ranjan R., Wan H., van Vactor D. (2002) Drosophila liprin alpha and the receptor phosphatase Dlar control synapse morphogenesis. „Neuron” 34:27-38.

Ko J., Kim S., Valtschanoff J.G., Shin H., Lee J.R., Sheng M., Premont R.T., Weinberg R.J., Kim E. (2003a) Interaction between liprin-alpha and G1T1 is required for AMPA receptor targeting. „J. Neurosci.” 23:1667-1677.

Ko J., Na M., Kim S., Lee J.R., Kim E. (2003b) Interaction o f the ERC family of RIM binding proteins with the liprin-alpha family of multidomain proteins. „J. Biol. Chem.” 278:42377-42385.

Koushika S.P., Richmond J.E., Hadwiger G., Weimer R.M., Jorgensen E.M., Nonet M.L. (2001) A post-docking role for active zone protein RIM. „Nat. Neurosci.” 4:997-1005.

Monier S., Jollivet F., Janoueix-Lerosey I., Johannes L., Goud B. (2002) Characterization of novel Rab6-interactingproteins involved in endosome-to-TGN transport. „Traffic” 3:289-297.

Ohara-Imaizumi M.,

Ohtsuka T., Matsushima S., Akimoto Y., Nishiwaki C., Nakamichi Y., Kikuta T., Nagai S., Kawakami H., Watanabe T., Nagamatsu S. (2005) ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction o f ELKS with exocytotic machinery analyzed by total internal reflection fluorescence microscopy. „Mol. Biol. Cell.” 16: 3289-3300. Ohtsuka T., Takao-Rikitsu E., Inoue E., Inoue M., Takeuchi M., Matsubara K., Deguchi-Tawarada M., Satoh K., Morimoto K., Nakanishi H., Takai Y. (2002) Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with R1M1 and Munc13-1. „J. Cell. Biol.” 158:577-590.

Olsen O., Moore K.A., Fukata M., Kazuta T., Trinidad J.C., Kauer F.W., Streuli M., Misawa H., Burlingame A.L., Nicoll R.A., Bredt D.S. (2005) Neurotransmitter release regulated by a MALS-liprin-alphapresynaptic complex. „J. Cell. Biol.” 170:1127-1134.



Powell C.M., Schoch S., Monteggia L., Barrot M., Matos M.F., Feldmann N., Sudhof T.C., Nestler E.J. (2004) The presynaptic active zone protein RIMlałpha is critical for normal learning and memory. „Neuron” 42:143-153.

Richmond J.E., Davis W.S., Jorgensen E.M. (1999) UNC-13 is required for synaptic vesicle fusion in C. elegans. „Nat. Neurosci.” 2:959-964.

Schoch S., Castillo P.E., Jo T., Mukherjee K., Geppert M., Wang Y., Schmitz F., Malenka R.C., Sudhof T.C. (2002) RIMlalpha forms a protein scaffold for regulating neurotransmitter release at the active zone. „Nature” 415:321-326.

Schoch S., Gundelfinger E.D. (2006) Molecular organization of the presynaptic active zone. „Cell. Tissue Res.” 326:379-391.

Serra-Pages C., Medley Q.G., Tang M., Hart A., Streuli M. (1998) Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. „J. Biol. Chem.” 273:15611-15620.

Sheu L., Pasyk E.A., Ji J., Huang X., Gao X., Varoqueaux F., Brose N., Gaisano H.Y. (2003) Regulation of Insulin Exocytosis by Munc13-1. „J. Cell. Biol.” 278:27556-27563.

Shibasaki T., Sunaga Y., Seino S. (2004) Integration of ATP, cAMP, and Ca2+ signals in insulin granule exocytosis. „Diabetes” 53 Suppl 3:S59-62.

Takao-Rikitsu E., Mochida S., Inoue E., Deguchi-Tawarada M., Inoue M., Ohtsuka T., Takai Y. (2004) Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release. „J. Cell. Biol.” 164:301-311.

Tom Dieck S., Sanmarti-Vila L., Langnaese K., Richter K., Kindler S., Soyke A., Wex H., Smalla K.H., Kampf U., Franzer J.T., Stumm M., Garner C.C., Gundelfinger E.D. (1998) Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals. „J. Cell. Biol.” 142:499-509.

Varoqueaux F., Sigler A., Rhee J.S., Brose N., Enk C., Reim K., Rosenmund C. (2002) Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. „Proc. Natl. Acad. Sci. USA” 99:9037-9042.

Wang Y., Okamoto M., Schmitz F., Hofmann K., Sudhof T.C. (1997) RIM is a putative Rab3 effector in regulating synaptic-vesicle fusion. „Nature” 388:593-598.

Wang Y., Sugita S., Sudhof T.C. (2000) The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. „J. Biol. Chem.” 275:20033-20044.

Wang Y., Liu X., Biederer T., Sudhof T.C. (2002) A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones. „Proc. Natl. Acad. Sci. USA” 99:14464-14469.

Wang Y., Sudhof T.C. (2003) Genomic definition of RIM proteins: evolutionary amplification o f a family of synaptic regulatory proteins. „Genomics” 81:126-137.

Wang X., Kibschull M., Laue M.M., Lichte B., Petrasch-Parwez E., Kilimann M.W. (1999) Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with RIM and Bassoon and bindsprofilin. „J. Cell. Biol.” 147:151-162.

Wyszynski M., Kim E., Dunah A.W., Passafaro M., Valtschanoff J.G., Serra-Pages C., Streuli M., Weinberg R.J., Sheng M. (2002) Interaction between GRIP and liprin alpha/SYD2 is required for AMPA receptor targeting. „Neuron” 34:39-52.

Zhen M., Jin Y. (1999) The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans. „Nature” 401:371-375. Google Scholar